Silymarin: Friend or Foe of UV Exposed Keratinocytes?

Silymarin: Friend or Foe of UV Exposed Keratinocytes?

Blog Article

The application of natural plant extracts in UV-protection is popular and intensively studied.Silymarin (from Silibum marianum), a naturally occurring polyphenol, has recently received attention due to its antioxidant, anti-inflammatory and anti-apoptotic effects.However, its role in the UV-mediated keratinocyte cell response is still click here controversial.In this study, we investigated the effects of Silibum marianum extracts with different origins and formulations on UVA-exposed HaCaT keratinocytes in vitro.Our results show, that silymarin treatment caused an inverse dose-dependent photosensitivity relationship (at higher doses, a decrease in cell viability and ROS production) after UVA exposure.

The attenuation of the UVA-induced ROS generation after silymarin treatment was click here also observed.Moreover, silymarin pre-treatment increased the cyclobutane pyrimidine dimer photolesions in keratinocytes after UVA exposure.These results indicated the dual role of silymarin in UVA-exposed keratinocytes.It scavenges ROS but still induces phototoxicity.Based on our results dermatological applications of silymarin and related compounds should be considered very carefully.